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Article

Pharmacogenetics of Alkylator-Associated Acute Myeloid Leukemia

1 Jul 2006

Abstract excerpt

Therapy-related acute myeloid leukemia (t-AML) is a lethal late complication of alkylator chemotherapy. The genetic basis of susceptibility to t-AML is poorly understood. Both t-AML and de novo AML are complex genetic diseases, requiring cooperating mutations in interacting pathways for disease initiation and progression. Germline variants of these 'leukemia pathway' genes may cooperate with somatic mutations to...

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PMID: 16886897
DOI: 10.2217/14622416.7.5.719

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