Article
Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features.
Breast cancer research : BCR - 1 Jan 2010
Tung Nadine, Wang Yihong, Collins Laura C, Kaplan Jennifer, Li Hailun, Gelman Rebecca, Comander Amy H, Gallagher Bridget, Fetten Katharina, Krag Karen, Stoeckert Kathryn A, Legare Robert D, Sgroi Dennis, Ryan Paula D, Garber Judy E, Schnitt Stuart J
Abstract excerpt
INTRODUCTION: Most breast cancers that occur in women with germline BRCA1 mutations are estrogen receptor-negative (ER-) and also typically lack expression of progesterone receptor (PR) and HER2 overexpression. We undertook a study to assess the clinical factors that predict for an estrogen receptor positive (ER+) breast cancer in BRCA1 mutation carriers and to characterize the pathologic features of these...
Topics
- Adult
- Aged
- Breast Neoplasms
- Case-Control Studies
- Female
- Genes, BRCA1
- Heterozygote
- Humans
- Middle Aged
- Mutation