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Article

Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis.

Annals of surgical oncology - 1 Sept 2007

King Tari A, Li Weiwei, Brogi Edi, Yee Cindy J, Gemignani Mary L, Olvera Narciso, Levine Douglas A, Norton Larry, Robson Mark E, Offit Kenneth, Borgen Patrick I, Boyd Jeff

Abstract excerpt

BACKGROUND: For individuals genetically predisposed to breast and ovarian cancer through inheritance of a mutant BRCA allele, somatic loss of heterozygosity affecting the wild-type allele is considered obligatory for cancer initiation and/or progression. However, several lines of evidence suggest that phenotypic effects may result from BRCA haploinsufficiency. METHODS: Archival fixed and embedded tissue specimens...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17597348
DOI: 10.1245/s10434-007-9372-1

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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