Loss of BRCA1 protein expression as indicator of the BRCAness phenotype is associated with favorable overall survival after complete resection of sporadic ovarian cancer.

doi:10.1097/IGC.0b013e318227c990

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Article

Loss of BRCA1 protein expression as indicator of the BRCAness phenotype is associated with favorable overall survival after complete resection of sporadic ovarian cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Nov 2011

Radosa Marc P, Häfner Norman, Camara Oumar, Diebolder Herbert, Mothes Anke, Winzer Harald, Jansen Lars, Dürst Matthias, Runnebaum Ingo B

Abstract excerpt

OBJECTIVE: Hereditary epithelial ovarian cancers (EOCs) not expressing functional BRCA1 protein are characterized by defects in homologous recombination DNA repair, rendering such tumors more sensitive to DNA damaging agents and synthetic lethality, that is, poly-ADP-ribose-polymerase inhibitor treatment. The aim of this study was to evaluate the use of BRCA1 immunohistochemistry (IHC) for EOC prognosis and...

Topics

Adenocarcinoma
Adult
Aged
Antineoplastic Agents
BRCA1 Protein
Biomarkers, Tumor
Carboplatin
Female
Germany
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

Middle Aged

Ovarian Neoplasms

Paclitaxel

Phenotype

Retrospective Studies

Source

Open in PubMed

Identifiers

PMID: 21897273
DOI: 10.1097/IGC.0b013e318227c990

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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