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P53, p21, and p73 gene polymorphisms in gastric carcinoma.

Hepato-gastroenterology - 1 Jan 2000

Shirai Osamu, Ohmiya Naoki, Taguchi Ayumu, Nakamura Masanao, Kawashima Hiroki, Miyahara Ryoji, Itoh Akihiro, Hirooka Yoshiki, Watanabe Osamu, Ando Takafumi, Goto Yasuyuki, Hamajima Nobuyuki, Goto Hidemi

Abstract excerpt

BACKGROUND/AIMS: The aim of this study was to evaluate the association of genetic polymorphisms of p53, p21, and p73 genes with susceptibility to gastric carcinoma (GC), its clinicopathologic features, and prognosis. METHODOLOGY: In a case-control study including 419 controls and 389 patients with sporadic GC, single nucleotide polymorphisms (SNPs) of p53 Arg72Pro, p21 Ser31Arg, and p73 G4C14-to-A4T14 at exon 2...

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PMID: 21443127

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