Article
P53 mutations in colorectal cancer from northern Iran: Relationships with site of tumor origin, microsatellite instability and K-ras mutations.
Journal of cellular physiology - 1 Aug 2008
Mahdavinia Mahboobeh, Bishehsari Faraz, Verginelli Fabio, Cumashi Albana, Lattanzio Rossano, Sotoudeh Masoud, Ansari Reza, Semeraro Daniela, Hormazdi Mahshid, Fakheri Hafez, Rakhshani Naser, De Lellis Laura, Curia Maria Cristina, Cama Alessandro, Piantelli Mauro, Malekzadeh Reza, Iacobelli Stefano, Mariani-Costantini Renato
Abstract excerpt
CRC-associated P53 mutations have not been studied extensively in non-Western countries at relatively low CRC risk. We examined, for the first time, 196 paraffin-embedded CRC cases from Northern Iran for mutations in P53 exons 5-8 using PCR-direct sequencing. P53 status and mutation site/type were correlated with nuclear protein accumulation, clinicopathologic variables and data on K-ras mutations and high-level...
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