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Article

The genetics of Crohn's disease.

Annual review of genomics and human genetics - 1 Jan 2009

Van Limbergen Johan, Wilson David C, Satsangi Jack

Abstract excerpt

From epidemiological data, based on concordance data in family studies, via linkage analysis to genome-wide association studies, we and others have accumulated robust evidence implicating more than 30 distinct genomic loci involved in the genetic susceptibility to Crohn's disease (CD). These loci encode genes involved in a number of homeostatic mechanisms: innate pattern recognition receptors (NOD2/CARD15, TLR4,...

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Source

Identifiers

PMID: 19453248
DOI: 10.1146/annurev-genom-082908-150013

Genes

CARD9
CCR6
DLG5
DMBT1
ICOSLG
IRGM
ITLN1
JAK2
MST1
NOD2
PTGER4
PTPN2
PTPN22
STAT3
TLR4
TNFSF15
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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