Article
Two independent genetic factors responsible for the associations of the IBD5 locus with Crohn's disease in the Czech population.
Inflammatory bowel diseases - 1 Jul 2011
Hradsky Ondrej, Dusatkova Petra, Lenicek Martin, Bronsky Jiri, Duricova Dana, Nevoral Jiri, Vitek Libor, Lukas Milan, Cinek Ondrej
Abstract excerpt
BACKGROUND: The role of the IBD5 locus in development of Crohn's disease (CD) has not been clarified. In the Czech population we examined its genetic association using variants of the SLC22A4 (rs1050152), SLC22A5 (rs2631367), two single nucleotide polymorphisms (SNPs) shown to be associated with CD in genome-wide studies (rs6596075 and rs2188962), and four SNPs previously shown to tag the haplotype blocks 4, 7,...
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