Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of heparanase-1 expression by mutant B-Raf kinase: role of GA binding protein in heparanase-1 promoter activation.

Neoplasia (New York, N.Y.) - 1 Nov 2010

Rao Geetha, Liu Dingxie, Xing Mingzhao, Tauler Jordi, Prinz Richard A, Xu Xiulong

Abstract excerpt

Heparanase-1 (HPR1), an endoglycosidase that specifically degrades heparan sulfate (HS) proteoglycans, is overexpressed in a variety of malignancies. Our present study sought to determine whether oncogene BRAF and RAS mutations lead to increased HPR1 expression. Reverse transcription-polymerase chain reaction analysis revealed that HPR1 gene expression was increased in HEK293 cells transiently transfected with a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Enzymologic
Share to Glucuronidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heparin

Share to Heparitin Sulfate

Share to Luciferases

Share to Oligosaccharides

Share to ras Proteins

Share to Response Elements

Source

Open in PubMed Open full text

Identifiers

PMID: 21076620
DOI: 10.1593/neo.10790
PMCID: PMC2978917

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of heparanase-1 expression by mutant B-Raf kinase: role of GA binding protein in heparanase-1 promoter activation.PMID 21076620Read ↗

Trans-activation of heparanase promoter by ETS transcription factors.Semantic proximity Read ↗

Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype.Semantic proximity Read ↗

Antisense-mediated suppression of Heparanase gene inhibits melanoma cell invasion.Semantic proximity Read ↗

Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation.Semantic proximity Read ↗

Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype.Semantic proximity Read ↗

Allele loss and down-regulation of heparanase gene are associated with the progression and poor prognosis of hepatocellular carcinoma.Semantic proximity Read ↗

JAK-2 V617F mutation increases heparanase procoagulant activity.Semantic proximity Read ↗

Dominant-negative CREB inhibits heparanase functionality and melanoma cell invasion.Semantic proximity Read ↗

Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2.Semantic proximity Read ↗

Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.Semantic proximity Read ↗

Cloning, expression, and characterization of an alternatively spliced variant of human heparanase.Semantic proximity Read ↗

Relationships between heparanase activity and increasing metastatic potential of fibroblasts transfected with various oncogenes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.