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Article

Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.

The Journal of biological chemistry - 21 Nov 2008

Purushothaman Anurag, Chen Ligong, Yang Yang, Sanderson Ralph D

Abstract excerpt

High levels of heparanase are an indicator of poor prognosis in myeloma patients, and up-regulation of the enzyme enhances tumor growth, angiogenesis, and metastasis in animal models. At least part of the impact of heparanase in driving the aggressive tumor phenotype is due to its effect on increasing the expression and shedding of the heparan sulfate proteoglycan syndecan-1, a molecule known to promote myeloma...

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Source

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Identifiers

PMID: 18812315
DOI: 10.1074/jbc.M806266200
PMCID: PMC2583309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.PMID 18812315Read ↗

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