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Article

Trans-activation of heparanase promoter by ETS transcription factors.

Oncogene - 13 Feb 2003

Lu W C, Liu Y N, Kang B B, Chen J H

Abstract excerpt

The remodeling of extracellular matrix (ECM) is an important process required for cancer cells to turn into invasive and metastatic cancer cells. To dissolve the protein components of ECM, matrix metalloproteinases are some of the essential enzymes. Another ECM remodeling enzyme is the heparanase (Hpa) that digests the heparin sulfate component of the matrix. In metastatic cancer cells the Hpa gene is...

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Source

Identifiers

PMID: 12584571
DOI: 10.1038/sj.onc.1206201

Genes

ETS1
ETS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Trans-activation of heparanase promoter by ETS transcription factors.PMID 12584571Read ↗

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