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Article

Allele loss and down-regulation of heparanase gene are associated with the progression and poor prognosis of hepatocellular carcinoma.

PloS one - 1 Jan 2012

Huang Guo-Liang, Li Bin-Kui, Zhang Mei-Yin, Wei Rong-Rong, Yuan Yun-Fei, Shi Ming, Chen Xiao-Qian, Huang Long, Zhang Hui-Zhong, Liu Wanqing, Huang Bi-Jun, Li Honghua, Zheng Xiao-Feng, Luo Xian-Rong, Wang Hui-Yun

Abstract excerpt

OBJECTIVES: The role of heparanase (HPSE) gene in cancers including hepatocellular carcinoma (HCC) is currently controversial. This study was aimed at investigating the impact of genetic alteration and expression change of HPSE on the progression and prognosis of HCC. METHODS: The HPSE gene was studied in three different aspects: (1) loss of heterozygosity (LOH) by a custom SNP microarray and DNA copy number by...

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Identifiers

PMID: 22952874
DOI: 10.1371/journal.pone.0044061
PMCID: PMC3432106

Genes

HPSE
AFP

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