Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal lesion formation following unilateral ureteral obstruction in mice in vivo.

doi:10.1254/jphs.10143fp

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Article

Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal lesion formation following unilateral ureteral obstruction in mice in vivo.

Journal of pharmacological sciences - 1 Jan 2010

Morisada Naoya, Nomura Masayoshi, Nishii Hisae, Furuno Yumi, Sakanashi Mayuko, Sabanai Ken, Toyohira Yumiko, Ueno Susumu, Watanabe Seiji, Tamura Masahito, Matsumoto Tetsuro, Tanimoto Akihide, Sasaguri Yasuyuki, Shimokawa Hiroaki, Kusuhara Koichi, Yanagihara Nobuyuki, Shirahata Akira, Tsutsui Masato

Abstract excerpt

The role of nitric oxide (NO) derived from all three NO synthases (NOSs) in renal lesion formation remains to be fully elucidated. We addressed this point in mice lacking all NOSs. Renal injury was induced by unilateral ureteral obstruction (UUO). UUO caused significant renal lesion formation (tubular apoptosis, interstitial fibrosis, and glomerulosclerosis) in wild-type, singly, and triply NOS(-/-) mice....

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PMID: 21076238
DOI: 10.1254/jphs.10143fp

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