Article
Nitric oxide destabilizes Pias3 and regulates sumoylation.
PloS one - 31 Oct 2007
Qu Jing, Liu Guang-Hui, Wu Kaiyuan, Han Peiwei, Wang Peng, Li Jiangmei, Zhang Xu, Chen Chang
Abstract excerpt
Small ubiquitin-related protein modifiers (SUMO) modification is an important mechanism for posttranslational regulation of protein function. However, it is largely unknown how the sumoylation pathway is regulated. Here, we report that nitric oxide (NO) causes global hyposumoylation in mammalian cells. Both SUMO E2 conjugating enzyme Ubc9 and E3 ligase protein inhibitor of activated STAT3 (Pias3) were targets for...
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