Article
Chronic kidney disease induced in mice by reversible unilateral ureteral obstruction is dependent on genetic background.
American journal of physiology. Renal physiology - 1 Apr 2010
Puri Tipu S, Shakaib Mohammed I, Chang Anthony, Mathew Liby, Olayinka Oladunni, Minto Andrew W M, Sarav Menaka, Hack Bradley K, Quigg Richard J
Abstract excerpt
Chronic kidney disease (CKD) begins with renal injury; the progression thereafter depends upon a number of factors, including genetic background. Unilateral ureteral obstruction (UUO) is a well-described model of renal fibrosis and as such is considered a model of CKD. We used an improved reversible unilateral ureteral obstruction (rUUO) model in mice to study the strain dependence of development of CKD after...
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