Article
Severe dyslipidaemia, atherosclerosis, and sudden cardiac death in mice lacking all NO synthases fed a high-fat diet.
Cardiovascular research - 1 Sept 2010
Yatera Yasuko, Shibata Kiyoko, Furuno Yumi, Sabanai Ken, Morisada Naoya, Nakata Sei, Morishita Tsuyoshi, Toyohira Yumiko, Wang Ke-Yong, Tanimoto Akihide, Sasaguri Yasuyuki, Tasaki Hiromi, Nakashima Yasuhide, Shimokawa Hiroaki, Yanagihara Nobuyuki, Otsuji Yutaka, Tsutsui Masato
Abstract excerpt
AIMS: The precise role of the nitric oxide synthase (NOS) system in lipid metabolism remains to be elucidated. We addressed this point in mice that we have recently developed and that lack all three NOS isoforms. METHODS AND RESULTS: Wild-type (WT), singly, doubly, and triply NOS(-/-) mice were fed either a regular or high-cholesterol diet for 3-5 months. The high-cholesterol diet significantly increased serum...
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