Article
Effect of point mutations in the native simian virus 40 tumor antigen, and in synthetic peptides corresponding to the H-2Db-restricted epitopes, on antigen presentation and recognition by cytotoxic T lymphocyte clones.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 1992
Deckhut A M, Tevethia S S
Abstract excerpt
The effects on CTL recognition of individual amino acid substitutions within epitopes I, II, and III of SV40 tumor Ag (T Ag) were examined. Epitope I spans amino acids 207 to 215, and epitope II/III is within residues 223 to 231 of SV40 T Ag. An amino acid substitution at position 207 (Ala----Val...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Polyomavirus Transforming
- Clone Cells
- Epitopes
- H-2 Antigens
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Peptide Fragments