Selective reactivity of CD8-independent T lymphocytes to a cytotoxic T lymphocyte-selected H-2Kb mutant altered at position 222 in the alpha 3 domain.

doi:10.1002/eji.1830220306

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Article

Selective reactivity of CD8-independent T lymphocytes to a cytotoxic T lymphocyte-selected H-2Kb mutant altered at position 222 in the alpha 3 domain.

European journal of immunology - 1 Mar 1992

Shepherd S E, Sun R, Nathenson S G, Sheil J M

Abstract excerpt

To study the structural basis for specificity and affinity of cytotoxic T lymphocytes for major histocompatibility complex/peptide complexes, we have employed a cytotoxic T lymphocyte (CTL)-mediated immunoselection approach to obtain H-2Kb structural mutants which are resistant to lysis by a Kb-s...

Topics

Animals
CD8 Antigens
Cytotoxicity, Immunologic
H-2 Antigens
Mice
Mice, Inbred C57BL
Mutation
Structure-Activity Relationship
T-Lymphocytes, Cytotoxic

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