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Atg1 family kinases in autophagy initiation

6 May 2015

Abstract excerpt

Autophagosome formation, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. Among all Atg proteins, Atg1 kinase in yeast and its counterpart in higher eukaryotes, ULK1 kinase, function as the most upstream factor in this process and mediate autophagy initiation. In this review, we summarize current knowledge of the structure, molecular function, and regulation of Atg1 family...

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Autophagy in Disease and Therapy
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PMID: 25948417
DOI: 10.1007/s00018-015-1917-z

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