A cryptic meprin-like proteolytic activity in mouse kidney brush border membranes.

doi:10.1016/0020-711x(90)90205-h

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Article

A cryptic meprin-like proteolytic activity in mouse kidney brush border membranes.

The International journal of biochemistry - 1 Jan 1990

Macadam G C, Beynon R J, Bond J S

Abstract excerpt

1. Inbred mouse strains differ markedly in the expression of a kidney brush border metalloendopeptidase, meprin-a. 2. Brush border preparations from mice of the low-meprin-a phenotype (specific activities less than 5% of the high-meprin-a trait) contain a metallo-endopeptidase, meprin-b, that is larger than meprin-a, and which is inactive unless the membrane preparations are treated with trypsin. 3. This cryptic...

Topics

Animals
Blotting, Western
Coumarins
Dipeptides
Electrophoresis, Polyacrylamide Gel
Enzyme Activation
Hydrolysis
Kidney
Metalloendopeptidases
Mice
Mice, Inbred C3H
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microvilli

Papain

Phenotype

Protein Precursors

Substrate Specificity

Tiopronin

Source

Open in PubMed

Identifiers

PMID: 2282966
DOI: 10.1016/0020-711x(90)90205-h

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2282966-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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