Article
Principal-component-based multivariate regression for genetic association studies of metabolic syndrome components.
BMC genetics - 9 Nov 2010
Mei Hao, Chen Wei, Dellinger Andrew, He Jiang, Wang Meng, Yau Canddy, Srinivasan Sathanur R, Berenson Gerald S
Abstract excerpt
BACKGROUND: Quantitative traits often underlie risk for complex diseases. For example, weight and body mass index (BMI) underlie the human abdominal obesity-metabolic syndrome. Many attempts have been made to identify quantitative trait loci (QTL) over the past decade, including association studies. However, a single QTL is often capable of affecting multiple traits, a quality known as gene pleiotropy. Gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.