Article
Genetic dissection of histone function.
Methods (San Diego, Calif.) - 1 Aug 1998
Smith M M, Santisteban M S
Abstract excerpt
Mutational analysis is an essential tool for understanding the functions of genes within a living organism. The budding yeast Saccharomyces cerevisiae provides an excellent model system for dissecting the genetics of histone function at the molecular and cellular levels. A simple gene organization, plus a wide variety of genetic strategies, makes it possible to directly manipulate a specific histone gene in vitro...
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