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Article

Increased B cell proliferation and reduced Ig production in DREAM transgenic mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2010

Savignac Magali, Mellström Britt, Bébin Anne-Gaëlle, Oliveros Juan C, Delpy Laurent, Pinaud Eric, Naranjo Jose R

Abstract excerpt

DREAM/KChIP-3 is a calcium-dependent transcriptional repressor highly expressed in immune cells. Transgenic mice expressing a dominant active DREAM mutant show reduced serum Ig levels. In vitro assays show that reduced Ig secretion is an intrinsic defect of transgenic B cells that occurs without...

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Source

Identifiers

PMID: 21059893
DOI: 10.4049/jimmunol.1000152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21059893-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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