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Article

Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2021

Finney Joel, Kelsoe Garnett

Abstract excerpt

Stable, long-term culture of primary B lymphocytes has many potential scientific and medical applications, but remains an elusive feat. A major obstacle to long-term culture is that in vitro mitogens quickly drive B cells to differentiate into short-lived plasma cells (PCs). PC differentiation is governed by opposing teams of transcription factors: Pax5, Bach2, and Bcl6 suppress PC commitment, whereas IFN...

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Source

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Identifiers

PMID: 34389622
DOI: 10.4049/jimmunol.2100172
PMCID: PMC8395587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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