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Article

Genetic evidence that polysumoylation bypasses the need for a SUMO-targeted Ub ligase.

Genetics - 1 Jan 2011

Mullen Janet R, Das Mukund, Brill Steven J

Abstract excerpt

Saccharomyces cerevisiae cells lacking the Slx5-Slx8 SUMO-targeted Ub ligase display increased levels of sumoylated and polysumoylated proteins, and they are inviable in the absence of the Sgs1 DNA helicase. One explanation for this inviability is that one or more sumoylated proteins accumulate to toxic levels in sgs1Δ slx5Δ cells. To address this possibility, we isolated a second-site suppressor of sgs1Δ slx5Δ...

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Identifiers

PMID: 21059884
DOI: 10.1534/genetics.110.124347
PMCID: PMC3018298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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