Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination.

Molecular and cellular biology - 1 Sept 2007

Burgess Rebecca C, Rahman Sadia, Lisby Michael, Rothstein Rodney, Zhao Xiaolan

Abstract excerpt

Recombination is important for repairing DNA lesions, yet it can also lead to genomic rearrangements. This process must be regulated, and recently, sumoylation-mediated mechanisms were found to inhibit Rad51-dependent recombination. Here, we report that the absence of the Slx5-Slx8 complex, a newly identified player in the SUMO (small ubiquitin-like modifier) pathway, led to increased Rad51-dependent and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to DNA Repair
Share to Multiprotein Complexes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Rad51 Recombinase

Share to Rad52 DNA Repair and Recombination Protein

Share to RNA Polymerase I

Share to Small Ubiquitin-Related Modifier Proteins

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 17591698
DOI: 10.1128/MCB.00787-07
PMCID: PMC1952148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination.PMID 17591698Read ↗

The SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stress.Semantic proximity Read ↗

Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in Saccharomyces cerevisiae.Semantic proximity Read ↗

Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.Semantic proximity Read ↗

Srs2 and Mus81-Mms4 Prevent Accumulation of Toxic Inter-Homolog Recombination Intermediates.Semantic proximity Read ↗

Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks.Semantic proximity Read ↗

Deficient SUMO attachment to Flp recombinase leads to homologous recombination-dependent hyperamplification of the yeast 2 microm circle plasmid.Semantic proximity Read ↗

Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis.Semantic proximity Read ↗

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase.Semantic proximity Read ↗

Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targeting.Semantic proximity Read ↗

Suppression of genomic instability by SLX5 and SLX8 in Saccharomyces cerevisiae.Semantic proximity Read ↗

A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast.Semantic proximity Read ↗

A role for SUMO in nucleotide excision repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.