Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein.

Molecular and cellular biology - 1 Apr 2000

Li S J, Hochstrasser M

Abstract excerpt

Yeast Smt3 and its vertebrate homolog SUMO-1 are ubiquitin-like proteins (Ubls) that are reversibly ligated to other proteins. Like SMT3, SMT4 was first isolated as a high-copy-number suppressor of a defective centromere-binding protein. We show here that SMT4 encodes an Smt3-deconjugating enzyme, Ulp2. In cells lacking Ulp2, specific Smt3-protein conjugates accumulate, and the conjugate pattern is distinct from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes
Share to Cysteine Endopeptidases
Share to Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxyurea

Share to Mitosis

Share to Small Ubiquitin-Related Modifier Proteins

Share to SUMO-1 Protein

Share to Ubiquitins

Source

Open in PubMed Open full text

Identifiers

PMID: 10713161
DOI: 10.1128/MCB.20.7.2367-2377.2000
PMCID: PMC85410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein.PMID 10713161Read ↗

SUMO conjugation and deconjugation.Semantic proximity Read ↗

The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer.Semantic proximity Read ↗

The yeast SUMO isopeptidase Smt4/Ulp2 and the polo kinase Cdc5 act in an opposing fashion to regulate sumoylation in mitosis and cohesion at centromeres.Semantic proximity Read ↗

A new Saccharomyces cerevisiae strain with a mutant Smt3-deconjugating Ulp1 protein is affected in DNA replication and requires Srs2 and homologous recombination for its viability.Semantic proximity Read ↗

Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic evidence that polysumoylation bypasses the need for a SUMO-targeted Ub ligase.Semantic proximity Read ↗

The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions.Semantic proximity Read ↗

Characterization of SUMO-conjugating enzyme mutants in Schizosaccharomyces pombe identifies a dominant-negative allele that severely reduces SUMO conjugation.Semantic proximity Read ↗

Characterization of a fission yeast SUMO-1 homologue, pmt3p, required for multiple nuclear events, including the control of telomere length and chromosome segregation.Semantic proximity Read ↗

Pds5p regulates the maintenance of sister chromatid cohesion and is sumoylated to promote the dissolution of cohesion.Semantic proximity Read ↗

Cooperation of sumoylated chromosomal proteins in rDNA maintenance.Semantic proximity Read ↗

SUMOylation and deSUMOylation at a glanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.