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Article

An overview of RecQ helicases and related diseases.

Aging - 25 Jul 2025

Yiu Tsz-Ching, Tu Jiajie, Cheung Hoi-Hung

Abstract excerpt

RecQ helicases are known as "caretakers" of the genome for their conserved helicase activities to resolve different complex DNA structures. Aberrant accumulation of unsolved DNA structures could lead to defects in DNA replication, gene transcription, and unrepaired DNA lesions. Pathogenic mutations on BLM, WRN, and RECQL4 are associated with several pathological conditions, namely Bloom syndrome (BS), Werner...

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Source

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Identifiers

PMID: 40728512
DOI: 10.18632/aging.206291
PMCID: PMC12339026

Genes

BLM
RECQL4
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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