Article
Residues at the interface between zinc binding and winged helix domains of human RECQ1 play a significant role in DNA strand annealing activity.
Nucleic acids research - 18 Nov 2021
Mukhopadhyay Swagata, Das Tulika, Bose Madhuparna, Jain Chetan Kumar, Chakraborty Mayukh, Mukherjee Sunandan, Shikha Kumari, Das Amit K, Ganguly Agneyo
Abstract excerpt
RECQ1 is the shortest among the five human RecQ helicases comprising of two RecA like domains, a zinc-binding domain and a RecQ C-terminal domain containing the winged-helix (WH). Mutations or deletions on the tip of a β-hairpin located in the WH domain are known to abolish the unwinding activity. Interestingly, the same mutations on the β-hairpin of annealing incompetent RECQ1 mutant (RECQ1T1) have been reported...
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