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Article

Spondylarthritis in HLA-B27/human beta2-microglobulin-transgenic rats is not prevented by lack of CD8.

Arthritis and rheumatism - 1 Jul 2009

Taurog Joel D, Dorris Martha L, Satumtira Nimman, Tran Tri M, Sharma Rohit, Dressel Ralf, van den Brandt Jens, Reichardt Holger M

Abstract excerpt

OBJECTIVE: HLA-B27 predisposes to spondylarthritis by an unknown mechanism. A logical candidate mechanism is through recognition of B27 by CD8+ T cells. The purpose of this study was to examine the effects of a lack of CD8 on the spondylarthritis that develops in B27/human beta(2)-microglobulin (Hubeta(2)m)-transgenic rats. METHODS: A missense mutation in the CD8a gene that causes a loss of CD8alpha expression...

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Identifiers

PMID: 19565478
DOI: 10.1002/art.24599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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