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Article

T cell receptor-mediated selection of functional rat CD8 T cells from defined immature thymocyte precursors in short-term suspension culture.

The Journal of experimental medicine - 1 Mar 1991

Hünig T, Mitnacht R

Abstract excerpt

Recent results have indicated that positive and negative repertoire selection act on the major population of CD4,8 double-positive (DP) thymocytes that express 5-10-fold less T cell receptor (TCR) than mature T cells (i.e., they are TCRlow). Since DP cells obtained ex vivo are heterogeneous with regard to their stage within thymic selection, a homogeneous population of virgin DP cells suitable for selection...

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Identifiers

PMID: 1900076
DOI: 10.1084/jem.173.3.561
PMCID: PMC2118830

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