Article
T cell receptor-mediated selection of functional rat CD8 T cells from defined immature thymocyte precursors in short-term suspension culture.
The Journal of experimental medicine - 1 Mar 1991
Hünig T, Mitnacht R
Abstract excerpt
Recent results have indicated that positive and negative repertoire selection act on the major population of CD4,8 double-positive (DP) thymocytes that express 5-10-fold less T cell receptor (TCR) than mature T cells (i.e., they are TCRlow). Since DP cells obtained ex vivo are heterogeneous with...
Topics
- Animals
- Antigens, Differentiation, T-Lymphocyte
- CD8 Antigens
- Cells, Cultured
- Cytotoxicity, Immunologic
- DNA Replication
- Female
- Flow Cytometry
- Fluorescent Antibody Technique
- Lymphocyte Activation
- Male
- Phenotype
- Rats
- Rats, Inbred Lew
- Receptors, Antigen, T-Cell
- T-Lymphocytes
- Thymidine
- Thymus Gland