Article
Deficiencies in gut NK cell number and function precede diabetes onset in BB rats.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2004
Todd Derrick J, Forsberg Eric M, Greiner Dale L, Mordes John P, Rossini Aldo A, Bortell Rita
Abstract excerpt
Defects in the intestinal immune system may contribute to the pathogenesis of autoimmune diseases. Intraepithelial lymphocytes represent a substantial fraction of gut-associated lymphocytes, but their function in mucosal immunity is unclear. A newly described population of NK cells that spontaneously secrete IL-4 and IFN-gamma is present in the intraepithelial lymphocyte compartment of the rat. We hypothesized...
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