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Article

Patterns and extent of isotype-specificity in the murine H chain switch DNA rearrangement.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 1990

Schultz C, Petrini J, Collins J, Claflin J L, Denis K A, Gearhart P, Gritzmacher C, Manser T, Shulman M, Dunnick W

Abstract excerpt

We have analyzed the configuration of the H chain locus of 41 hybridomas by Southern blot analysis. Each H chain switch region was determined to be germ line, rearranged, or deleted. Including 13 previously analyzed hybridomas, 60% of those with rearrangements on both alleles showed a correlation of the two alleles, i.e., both the expressed and the nonexpressed alleles have rearranged to the same H chain constant...

Topics

Alleles
Animals
Blotting, Southern
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genes, Immunoglobulin
Hybridomas
Immunoglobulin Heavy Chains
Immunoglobulin Isotypes
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 2104891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2104891-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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