The intraclonal diversity and control of antibody isotype switch recombination.

Abstract excerpt

The configuration of the expressed and unexpressed IgH alleles within two groups of hybridomas, both derived from single clones of B cells at an intermediate stage of the immune response of one mouse, were characterized. The data obtained confirm that individual 'naive' B cells are totipotent in...

Topics

• Alleles
• Animals
• Antibody Diversity
• B-Lymphocytes
• Clone Cells
• Genes, Immunoglobulin
• Genes, Switch
• Hybridomas
• Immunoglobulin Isotypes
• Mice
• Phylogeny
• Recombination, Genetic