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Article

Ena drives invasive macrophage migration in <i>Drosophila</i> embryos

3 Nov 2010

Abstract excerpt

It is seldom the primary tumour that proves fatal in cancer, with metastasis the fundamental pathological process for disease progression. Upregulation of Mena, a member of the evolutionarily conserved Ena/VASP family of actin cytoskeletal regulators, promotes metastasis and invasive motility of breast cancer cells in vivo. To complement in vitro studies of Ena/VASP function in fibroblasts, we manipulated levels...

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PMID: 21045209
DOI: 10.1242/dmm.005694

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