Article
I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration.
The Journal of cell biology - 19 Apr 2010
Quinones Gabriel A, Jin Janet, Oro Anthony E
Abstract excerpt
Although directed cellular migration facilitates the coordinated movement of cells during development and repair, the mechanisms regulating such migration remain poorly understood. Missing-in-metastasis (MIM) is a defining member of the inverse Bin/Amphiphysin/Rvs domain (I-BAR) subfamily of lipid binding, cytoskeletal regulators whose levels are altered in a number of cancers. Here, we provide the first genetic...
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