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Article

Lessons from border cell migration in the <i>Drosophila</i> ovary: A role for myosin VI in dissemination of human ovarian cancer

14 May 2004

Abstract excerpt

Dissemination of ovarian cancer is a major clinical challenge and is poorly understood at the molecular level due to a lack of suitable experimental models. During normal development of the Drosophila ovary, a dynamic process called border cell migration occurs that resembles the migratory behavior of human ovarian cancer cells. In this study, we found that myosin VI, a motor protein that regulates border cell...

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PMID: 15146066
DOI: 10.1073/pnas.0400400101

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