Article

Cooperative NF-κB and Notch1 signaling promotes macrophage-mediated MenaINV expression in breast cancer

2023-01-03

Abstract excerpt

Metastasis is a multistep process that leads to the formation of clinically detectable tumor foci at distant organs and frequently patient demise. Only a subpopulation of breast cancer cells within the primary tumor can disseminate systemically and cause metastasis. To disseminate, cancer cells must express MenaINV, an isoform of the actin-regulatory protein Mena encoded by the ENAH gene that endows tumor cells w...

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Literature Corpus work: 0a43100f-50f3-52a3-8907-ba9747ee3b9b
DOI: 10.1101/2023.01.03.522642

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