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WNK1 Enhances Migration and Invasion in Breast Cancer Models

12 Jul 2021

Abstract excerpt

Metastasis is the major cause of mortality in patients with breast cancer. Many signaling pathways have been linked to cancer invasiveness, but blockade of few protein components has succeeded in reducing metastasis. Thus, identification of proteins contributing to invasion that are manipulable by small molecules may be valuable in inhibiting spread of the disease. The protein kinase with no lysine (K) 1 (WNK1)...

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PMID: 34253593
DOI: 10.1158/1535-7163.mct-21-0174

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