Article

Paclitaxel causes <i>de novo</i> induction of invasive breast cancer cells by repolarizing tumor-associated macrophages

2025-01-15

Abstract excerpt

Metastasis is the leading cause of breast cancer death, and tumor cells must migrate and invade to metastasize. Breast cancer cells that express the pro-metastatic actin regulatory protein MenaINV have an enhanced ability to migrate and intravasate within the primary tumor and extravasate at secondary sites. Though chemotherapy improves patient survival, treatment with paclitaxel leads to upregulation of MenaINV a...

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Literature Corpus work: de12adb3-0451-52e7-bf07-93efdd58cc92
DOI: 10.1101/2025.01.13.632767

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