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Double-Negative Feedback Loop between Reprogramming Factor LIN28 and microRNA <i>let-7</i> Regulates Aldehyde Dehydrogenase 1–Positive Cancer Stem Cells

7 Nov 2010

Abstract excerpt

A relatively rare aldehyde dehydrogenase 1 (ALDH1)-positive "stem cell-like" subpopulation of tumor cells has the unique ability to initiate and perpetuate tumor growth; moreover, it is highly resistant to chemotherapy and significantly associated with poor clinical outcomes. The development of more effective therapies for cancer requires targeting of this cell population. Using cDNA microarray analysis, we...

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PMID: 21045151
DOI: 10.1158/0008-5472.can-10-2388

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