Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility.

doi:10.1371/journal.pgen.1002259

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Article

Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility.

PLoS genetics - 1 Sept 2011

Chen Ao-Xiang, Yu Ke-Da, Fan Lei, Li Ji-Yu, Yang Chen, Huang A-Ji, Shao Zhi-Ming

Abstract excerpt

Previous studies have shown that let-7 can repress the post-transcriptional translation of LIN28, and LIN28 in turn could block the maturation of let-7, forming a double-negative feedback loop. In this study, we investigated the effect of germline genetic variants on regulation of the homeostasis of the let-7/LIN28 loop and breast cancer risk. We initially demonstrated that the T/C variants of rs3811463, a single...

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PMID: 21912531
DOI: 10.1371/journal.pgen.1002259
PMCID: PMC3164678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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