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Article

Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells.

eLife - 23 Apr 2021

Ogino Takashi, Matsunaga Naoya, Tanaka Takahiro, Tanihara Tomohito, Terajima Hideki, Yoshitane Hikari, Fukada Yoshitaka, Tsuruta Akito, Koyanagi Satoru, Ohdo Shigehiro

Abstract excerpt

Disruption of the circadian clock machinery in cancer cells is implicated in tumor malignancy. Studies on cancer therapy reveal the presence of heterogeneous cells, including breast cancer stem-like cells (BCSCs), in breast tumors. BCSCs are often characterized by high aldehyde dehydrogenase (ALDH) activity, associated with the malignancy of cancers. In this study, we demonstrated the negative regulation of ALDH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33890571
DOI: 10.7554/eLife.66155
PMCID: PMC8102063

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