Back to search

Article

The epithelial-mesenchymal transcription factor <i>SNAI1</i> represses transcription of the tumor suppressor miRNA <i>let-7</i> in cancer

2020-11-05

Abstract excerpt

We aimed to determine the mechanism of epithelial-mesenchymal transition (EMT)-induced stemness in cancer cells. Cancer relapse and metastasis are caused by rare stem-like cells within tumors. Studies of stem cell reprogramming have linked let-7 repression and acquisition of stemness with the EMT factor, SNAI1 . The mechanisms for the loss of let-7 in cancer cells are incompletely understood. In four carcinoma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
87595b57-bb22-565a-9e23-709cda5b867d
DOI
10.1101/2020.11.04.368688
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The epithelial-mesenchymal transcription factor <i>SNAI1</i> represses transcription of the tumor suppressor miRNA <i>let-7</i> in cancerDOI 10.1101/2020.11.04.368688
The Epithelial–Mesenchymal Transcription Factor SNAI1 Represses Transcription of the Tumor Suppressor miRNA let-7 in CancerSemantic proximity
Let-7 inhibits self-renewal of hepatocellular cancer stem-like cells through regulating the epithelial-mesenchymal transition and the Wnt signaling pathwaySemantic proximity
The effects of shRNA-mediated gene silencing of transcription factor SNAI1 on the biological phenotypes of breast cancer cell line MCF-7.Semantic proximity
Let-7i Reduces Aggressive Phenotype and Induces BRCAness in Ovarian Cancer CellsSemantic proximity
Let-7c restores radiosensitivity and chemosensitivity and impairs stemness in oral cancer cells through inhibiting interleukin-8.Semantic proximity
Coexpression of <i>Oct4</i> and <i>Nanog</i> Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell–Like Properties and Epithelial–Mesenchymal TransdifferentiationSemantic proximity
MiR-7 reduces the BCSC subset by inhibiting XIST to modulate the miR-92b/Slug/ESA axis and inhibit tumor growthSemantic proximity
7SK-enriched exosomes suppress the cancer phenotypes in human lung cancer cells: insights from 2D and microfluidic 3D in vitro models.Semantic proximity
LncRNA <i>OIP5-AS1</i> is overexpressed in undifferentiated oral tumors and integrated analysis identifies as a downstream effector of stemness-associated transcription factorsSemantic proximity
Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumorsSemantic proximity
let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B ComplexSemantic proximity
Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas.Semantic proximity
Select a neighboring publication to make it the new centre.