Article
Functional disassociation of the central and peripheral fatty acid amide signaling systems.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2004
Cravatt Benjamin F, Saghatelian Alan, Hawkins Edward G, Clement Angela B, Bracey Michael H, Lichtman Aron H
Abstract excerpt
Fatty acid amides (FAAs) constitute a large class of endogenous signaling lipids that modulate several physiological processes, including pain, feeding, blood pressure, sleep, and inflammation. Although FAAs have been proposed to evoke their behavioral effects through both central and peripheral mechanisms, these distinct signaling pathways have remained experimentally challenging to separate. Here, we report a...
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