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Article

A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.

Molecular pain - 1 Jan 2016

Carey Lawrence M, Slivicki Richard A, Leishman Emma, Cornett Ben, Mackie Ken, Bradshaw Heather, Hohmann Andrea G

Abstract excerpt

Fatty-acid amide hydrolase (FAAH) is the major enzyme responsible for degradation of anandamide, an endocannabinoid. Pharmacological inhibition or genetic deletion of FAAH (FAAH KO) produces antinociception in preclinical pain models that is largely attributed to anandamide-induced activation of cannabinoid receptors. However, FAAH metabolizes a wide range of structurally related, biologically active lipid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27178246
DOI: 10.1177/1744806916649192
PMCID: PMC4956176

Genes

FAAH
TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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