Article
FAAH genetic variation enhances fronto-amygdala function in mouse and human.
Nature communications - 3 Mar 2015
Dincheva Iva, Drysdale Andrew T, Hartley Catherine A, Johnson David C, Jing Deqiang, King Elizabeth C, Ra Stephen, Gray J Megan, Yang Ruirong, DeGruccio Ann Marie, Huang Chienchun, Cravatt Benjamin F, Glatt Charles E, Hill Matthew N, Casey B J, Lee Francis S
Abstract excerpt
Cross-species studies enable rapid translational discovery and produce the broadest impact when both mechanism and phenotype are consistent across organisms. We developed a knock-in mouse that biologically recapitulates a common human mutation in the gene for fatty acid amide hydrolase (FAAH) (C385A; rs324420), the primary catabolic enzyme for the endocannabinoid anandamide. This common polymorphism impacts the...
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