Article
Evaluation of allelic expression of imprinted genes in adult human blood.
PloS one - 21 Oct 2010
Frost Jennifer M, Monk Dave, Stojilkovic-Mikic Taita, Woodfine Kathryn, Chitty Lyn S, Murrell Adele, Stanier Philip, Moore Gudrun E
Abstract excerpt
BACKGROUND: Imprinted genes are expressed from only one allele in a parent-of-origin dependent manner. Loss of imprinted (LOI) expression can result in a variety of human disorders and is frequently reported in cancer. Biallelic expression of imprinted genes in adult blood has been suggested as a useful biomarker and is currently being investigated in colorectal cancer. In general, the expression profiles of...
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