Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Predisposition Favors the Acquisition of Stable Artemisinin Resistance in Malaria Parasites

2 Nov 2010

Abstract excerpt

The emergence of artemisinin-resistant Plasmodium falciparum malaria jeopardizes efforts to control this infectious disease. To identify factors contributing to reduced artemisinin susceptibility, we have employed a classical genetic approach by analyzing artemisinin responses in the F1 progeny of a genetic cross. Our data show that reduced artemisinin susceptibility is a multifactorial trait, with pfmdr1 and two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Drug Discovery Methods
Share to Malaria Research and Control
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21041511
DOI: 10.1128/aac.00916-10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Predisposition Favors the Acquisition of Stable Artemisinin Resistance in Malaria ParasitesPMID 21041511Read ↗

Multiple drug resistance genes in malaria -- from epistasis to epidemiology.Semantic proximity Read ↗

Observing in real time the evolution of artemisinin resistance in Plasmodium falciparum.Semantic proximity Read ↗

Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum.Semantic proximity Read ↗

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites.Semantic proximity Read ↗

Fitness of artemisinin-resistant Plasmodium falciparum in vitro.Semantic proximity Read ↗

Peeling the onion: how complex is the artemisinin resistance genetic trait of malaria parasites?Semantic proximity Read ↗

Plasmodium falciparum malaria: Convergent evolutionary trajectories towards delayed clearance following artemisinin treatment.Semantic proximity Read ↗

The interplay between drug resistance and fitness in malaria parasitesSemantic proximity Read ↗

How can we identify parasite genes that underlie antimalarial drug resistance?Semantic proximity Read ↗

Plasmodium falciparum drug resistance phenotype as assessed by patient antimalarial drug levels and its association with pfmdr1 polymorphisms.Semantic proximity Read ↗

Integration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparumSemantic proximity Read ↗

Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.