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Article

How can we identify parasite genes that underlie antimalarial drug resistance?

Pharmacogenomics - 1 Jan 2011

Anderson Tim, Nkhoma Standwell, Ecker Andrea, Fidock David

Abstract excerpt

This article outlines genome-scale approaches that can be used to identify mutations in malaria (Plasmodium) parasites that underlie drug resistance and contribute to treatment failure. These approaches include genetic mapping by linkage or genome-wide association studies, drug selection and characterization of resistant mutants, and the identification of genome regions under strong recent selection. While these...

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Identifiers

PMID: 21174623
DOI: 10.2217/pgs.10.165
PMCID: PMC3148835

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